|Table of Contents|

LOXL2 promotes the invasion of human breast cancer cell line MCF-7

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2015 06
Page:
749-751
Research Field:
Publishing date:

Info

Title:
LOXL2 promotes the invasion of human breast cancer cell line MCF-7
Author(s):
Cao Yubo1; Yu Tao2; Hui Linping2; Li Qin2
1.Department of Medical Oncology;2.Central Laboratory，The Fourth Hospital of China Medical University,Liaoning Shenyang 110032,China.
Keywords:
LOXL2; invasion; breast cancer
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2015.06.06
Abstract:
Objective:To observe LOXL2 how to affect the invasion of human breast cancer MCF-7 cells.Methods:Flag-LOXL2 plasmid was transfected into human breast cancer MCF-7 cells,the changes of LOXL2 protein expression were assayed by using Western blotting.Transwell invasion assay was used to assess the invasive ability of breast cancer cells.Western blot detected the effect of LOXL2 protein on the expression of MMP2/MMP9.Results:Flag-LOXL2 plasmid was transiently transfected into human breast cancer MCF-7 cells,the expression of LOXL2 protein increased significantly,which promoted the invasion of MCF-7 cells and upregulated the expression of MMP2/MMP9.Conclusion:LOXL2 promotes the invasion of human breast cancer MCF-7 cells and raises the expression of MMP2/MMP9.

References:

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Memo

Memo:
国家自然科学基金（编号：31201053；81372337）
Last Update: 2015-02-02