|Table of Contents|

Relationship between the expression of CD44v6 and MMP-2 in breast carcinoma and lymph node metastasis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2011 02
Page:
272-0273
Research Field:
Publishing date:

Info

Title:
Relationship between the expression of CD44v6 and MMP-2 in breast carcinoma and lymph node metastasis
Author(s):
WANG Xiu-qing; LIU Hui-min; ZHAO Yan-long; SHI Zhi-min
Department of Pathology, the Hospital of Hebei Engineering University Medical College, Handan 056002, China.
Keywords:
infiltrating ductal carcinoma; CD44v6; MMP-2; metastasis
PACS:
R737.9
DOI:
-
Abstract:
Objective： To detect the expression of CD44v6 and MMP-2 in infiltrating ductal carcinoma, and explore their relationship with lymph node metastasis. Methods： The expression of CD44v6 and MMP-2 was studied in 100 cases of infiltrating ductal carcinoma by SP immunohistochemistry. Results: The positive expression of CD44v6 protein in normal breast tissue and infiltrating ductal carcinoma was 12.5%(5/40),87% (87/100) respectively,and the positive rate of CD44v6 in patients with lymph node metastasis(56/60) significantly higher than those without lymph node metastasis(P<0.05).The positive expression of MMP-2 protein in normal breast tissue and infiltrating ductal carcinoma was 0(0/40),94%(94/100) respectively, and the positive rate of MMP-2 in patients with lymph node metastasis(59/60) significantly higher than those without lymph node metastasis(P<0.05). Conclusion: CD44v6 and MMP-2 protein are highly expressed in infiltrating ductal carcinoma and are all related with lymph node metastasis(P<0.05),combined detection of CD44v6 and MMP-2 is useful to estimation of infiltrating ductal carcinoma malignancy and metastatic potential.

References:

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