|Table of Contents|

Methylation of 14-3-3σgene in papillary thyroid carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2011 02
Page:
255-0257
Research Field:
Publishing date:

Info

Title:
Methylation of 14-3-3σgene in papillary thyroid carcinoma
Author(s):
FAN Zhao; YE Jing; ZHANG Fang-ting; CHEN Qi-ming
Peking University Shenzhen Hospital，Shenzhen 518036，China．
Keywords:
thyroid carcinoma; papillary; 14-3-3σ; methylation
PACS:
R736.1
DOI:
-
Abstract:
Objective：To study the relation between methylation of 14-3-3σ gene in promoter region and papillary thyroid carcinoma. Methods：Methylation of 14-3-3σ gene in 48 cases of papillary thyroid carcinoma tissues and 21 cases of non-thyroid carcinoma tissues was examined by methylation-specific polymerase chain reaction(MSP). Results：The methylation of 14-3-3σ gene was detected in 34 cases of 48 cases of papillary thyroid carcinoma tissues. The methylation rate was 70.8%. 10 cases in 21 cases of non-thyroid carcinoma tissues had methylation. The methylation rate was 47.6%. The difference was not significant (P>0.05). Conclusion：More research is needed to define the methylated effect of 14-3-3σ gene in thyroid carcinoma.

References:

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